COMPARATIVE ESTIMATION OF LIPID PEROXIDATION AND GLUTATHIONE SYSTEM CHANGES IN LIVER                            TISSUES OF RATS WITH WALKER-256 CARCINOMA AS A RESULT OF USING PYRIMIDINE                        AND 3-HYDROXYPYRIDINE DERIVATIVES WITH DOXORUBICIN AND PACLITAXEL 

Siprov Aleksandr Vladimirovich, Doctor of medical sciences, professor, sub-department of pharmacology and clinical pharmacology with a course of pharmaceutical technology, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), alek-s13@mail.ru
Kostina Yuliya Aleksandrovna, Postgraduate student, Medical Institute, Ogarev Mordovia State University (68 Bolshevistskaya street, Saransk, Russia), bazunova@yandex.ru  

615.277.3:612.123.35 

Background. The goal of the study is to carry out a comparative analysis of lipid peroxidation processes and glutation system in the liver of rats with Walker-256 carcinoma at the influence of xymedon, mexidol and kardioxane at the chemotherapy.
Materials and methods. The study was carried out in 100 female Wistar rats, weighing 150–250 g. Doxorubicin (4 mg/kg) and paclitaxel (6 mg/kg) were introduced intraperitoneally once. Xymedon (100 mg/kg) and mexidol (50 mg/kg) were were introduced intramuscularly. Kardioxan (80 mg/kg) was introduced intraperitoneally 20 min before introduction of cytostatics.
Results. It is found that Xymedon reduces malondialdehyde and Schiff bases level as opposed to mexidol and kardioxane. Combination of xymedon with mexidol reduces triene conjugates level additionally. Mexidol corrects the reduced glutathione level and enzymes activity of its redox-cycling more efficiently than xymedon and kardioxane. However the combination of xymedon with mexidol corrects these indicators more efficiently.
Conclusions. The combination of xymedon with mexidol inhibits lipid peroxidation and increases reserve resources of the glutathione system in the liver more efficiently than the separate use of these medicines or the use of kardioxane. 

xymedon, mexidol, doxorubicin, paclitaxel, lipid peroxidation, glutathione. 

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